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PICSI (Physiological Intracytoplasmic Sperm Injection) is a reproductive technology used in in vitro fertilization (IVF). This technology is used to select the best quality (mature) sperm before injecting it into a woman’s egg. PICSI aims to improve the fertilization success rate and increase the chances of a healthy pregnancy.
The PICSI process is carried out using a special dish that has been coated with hyaluronan enzymes. which serves as a natural marker on mature sperm. The sperm to be used will be placed on top of the hyaluronic acid layer and allowed to adhere for a few minutes. Good quality sperm will naturally adhere to hyaluronic acid, while less optimal sperm will remain on top. Next, the sperm that has adhered to hyaluronic acid will be selected and injected directly into the woman’s egg, with the hope of increasing the chances of fertilization success. PICSI technology is usually used in couples with fertility problems with a fairly high DNA fragmentation rate.